Jamie George limped off with a hamstring problem late in Saracens' Champions Cup defeat by Castres to make the England vice-captain a Six Nations doubt.
England, British and Irish Lions and Leicester Tigers back Anthony Watson has been forced to retire from rugby on medical grounds.
England Red Roses head coach John Mitchell admits changing the captaincy from Marlie Packer to Zoe Aldcroft "wasn't nice" for the former, nor for Mitchell himself.
Maro Itoje has replaced Jamie George as England captain ahead of their upcoming Six Nations campaign.
England flanker Sam Underhill is unlikely to play any part in the Six Nations after his club Bath revealed he requires an ankle operation.
England wing Immanuel Feyi-Waboso will miss the entire Six Nations because of the dislocated shoulder sustained on club duty for Exeter last month.
England are to play two Tests against Argentina in July in their first tour to South America since 2017.
We look at the reasons behind RFU chief executive Bill Sweeney facing demands for his removal as the community game in England revolts.
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